Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management?
Identifieur interne : 001039 ( Main/Exploration ); précédent : 001038; suivant : 001040Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management?
Auteurs : Antoni Sureda [Espagne] ; Javad Alizadeh [Canada] ; Seyed Fazel Nabavi [Iran] ; Ioana Berindan-Neagoe [Roumanie] ; Cosmin Andrei Cismaru [Roumanie] ; Philippe Jeandet [France] ; Marek J. Łos [Pologne] ; Emilio Clementi [Italie] ; Seyed Mohammad Nabavi [Iran] ; Saeid Ghavami [Pologne]Source :
- European journal of pharmacology [ 1879-0712 ] ; 2020.
Descripteurs français
- KwdFr :
- Betacoronavirus (métabolisme), Endocytose (effets des médicaments et des substances chimiques), Endosomes (effets des médicaments et des substances chimiques), Endosomes (métabolisme), Humains (MeSH), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Ionophores (pharmacologie), Ionophores (usage thérapeutique), Pandémies (MeSH), Peptidyl-Dipeptidase A (métabolisme), Pneumocytes (cytologie), Pneumocytes (effets des médicaments et des substances chimiques), Pneumocytes (métabolisme), Pneumocytes (virologie), Pneumopathie virale (traitement médicamenteux), Pneumopathie virale (virologie), Réponse aux protéines mal repliées (effets des médicaments et des substances chimiques), Réticulum endoplasmique (effets des médicaments et des substances chimiques), Réticulum endoplasmique (métabolisme), Vésicules tapissées de clathrine (effets des médicaments et des substances chimiques), Vésicules tapissées de clathrine (métabolisme).
- MESH :
- cytologie : Pneumocytes.
- effets des médicaments et des substances chimiques : Endocytose, Endosomes, Pneumocytes, Réponse aux protéines mal repliées, Réticulum endoplasmique, Vésicules tapissées de clathrine.
- métabolisme : Betacoronavirus, Endosomes, Peptidyl-Dipeptidase A, Pneumocytes, Réticulum endoplasmique, Vésicules tapissées de clathrine.
- pharmacologie : Ionophores.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Ionophores.
- virologie : Infections à coronavirus, Pneumocytes, Pneumopathie virale.
- Humains, Pandémies.
English descriptors
- KwdEn :
- Alveolar Epithelial Cells (cytology), Alveolar Epithelial Cells (drug effects), Alveolar Epithelial Cells (metabolism), Alveolar Epithelial Cells (virology), Betacoronavirus (metabolism), Clathrin-Coated Vesicles (drug effects), Clathrin-Coated Vesicles (metabolism), Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Endocytosis (drug effects), Endoplasmic Reticulum (drug effects), Endoplasmic Reticulum (metabolism), Endosomes (drug effects), Endosomes (metabolism), Humans (MeSH), Ionophores (pharmacology), Ionophores (therapeutic use), Pandemics (MeSH), Peptidyl-Dipeptidase A (metabolism), Pneumonia, Viral (drug therapy), Pneumonia, Viral (virology), Unfolded Protein Response (drug effects).
- MESH :
- chemical , metabolism : Peptidyl-Dipeptidase A.
- chemical , pharmacology : Ionophores.
- cytology : Alveolar Epithelial Cells.
- drug effects : Alveolar Epithelial Cells, Clathrin-Coated Vesicles, Endocytosis, Endoplasmic Reticulum, Endosomes, Unfolded Protein Response.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- metabolism : Alveolar Epithelial Cells, Betacoronavirus, Clathrin-Coated Vesicles, Endoplasmic Reticulum, Endosomes.
- chemical , therapeutic use : Ionophores.
- virology : Alveolar Epithelial Cells, Coronavirus Infections, Pneumonia, Viral.
- Humans, Pandemics.
Abstract
In December 2019, many pneumonia cases with unidentified sources appeared in Wuhan, Hubei, China, with clinical symptoms like viral pneumonia. Deep sequencing analysis of samples from lower respiratory tract revealed a novel coronavirus, called 2019 novel coronavirus (2019-nCoV). Currently there is a rapid global spread. World Health Organization declare the disease a pandemic condition. The pathologic source of this disease was a new RNA virus from Coronaviridae family, which was named COVID-19. SARS-CoV-2 entry starts with the binding of the spike glycoprotein expressed on the viral envelope to ACE2 on the alveolar surface followed by clathrin-dependent endocytosis of the SARS-CoV-2 and ACE2 complex. SARS-CoV-2 enters the cells through endocytosis process, which is possibly facilitated, via a pH dependent endosomal cysteine protease cathepsins. Once inside the cells, SARS-CoV-2 exploits the endogenous transcriptional machinery of alveolar cells to replicate and spread through the entire lung. Endosomal acidic pH for SARS-CoV-2 processing and internalization is critical. After entering the cells, it possibly activates or hijack many intracellular pathways in favor of its replication. In the current opinion article, we will explain the possible involvement of unfolded protein response as a cellular stress response to the SARS-CoV-2 infection.
DOI: 10.1016/j.ejphar.2020.173288
PubMed: 32561291
PubMed Central: PMC7297682
Affiliations:
- Canada, Espagne, France, Iran, Italie, Pologne, Roumanie
- Champagne-Ardenne, Grand Est, Manitoba
- Reims, Winnipeg
- Université du Manitoba
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The Center for Advanced Medicine - Medfuture- "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; The Department for Functional Genomics and Experimental Pathology, The Oncology Institute, "Prof. Dr. Ion Chiricuta", Cluj-Napoca</wicri:regionArea><wicri:noRegion>Cluj-Napoca</wicri:noRegion></affiliation></author><author><name sortKey="Cismaru, Cosmin Andrei" sort="Cismaru, Cosmin Andrei" uniqKey="Cismaru C" first="Cosmin Andrei" last="Cismaru">Cosmin Andrei Cismaru</name><affiliation wicri:level="1"><nlm:affiliation>Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Functional Sciences, Immunology and Allergology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Functional Sciences, Immunology and Allergology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca</wicri:regionArea><wicri:noRegion>Cluj-Napoca</wicri:noRegion></affiliation></author><author><name sortKey="Jeandet, Philippe" sort="Jeandet, Philippe" uniqKey="Jeandet P" first="Philippe" last="Jeandet">Philippe Jeandet</name><affiliation wicri:level="3"><nlm:affiliation>Research Unit, Induced Resistance and Plant Bioprotection, EA 4707, SFR Condorcet FR CNRS 3417, Faculty of Sciences, University of Reims Champagne-Ardenne, PO Box 1039, 51687, Reims Cedex 2, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Research Unit, Induced Resistance and Plant Bioprotection, EA 4707, SFR Condorcet FR CNRS 3417, Faculty of Sciences, University of Reims Champagne-Ardenne, PO Box 1039, 51687, Reims Cedex 2</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Los, Marek J" sort="Los, Marek J" uniqKey="Los M" first="Marek J" last="Łos">Marek J. Łos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Pomeranian Medical University, Szczecin, Poland. Electronic address: mjelos@gmail.com.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Clementi, Emilio" sort="Clementi, Emilio" uniqKey="Clementi E" first="Emilio" last="Clementi">Emilio Clementi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical and Clinical Sciences, "Luigi Sacco" (DIBIC), Università Degli Studi di Milano, 20157, Milano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedical and Clinical Sciences, "Luigi Sacco" (DIBIC), Università Degli Studi di Milano, 20157, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Nabavi, Seyed Mohammad" sort="Nabavi, Seyed Mohammad" uniqKey="Nabavi S" first="Seyed Mohammad" last="Nabavi">Seyed Mohammad Nabavi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Translational Medicine, Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Tehran, Iran; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: Nabavi208@gmail.com.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Division of Translational Medicine, Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Tehran, Iran; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Ghavami, Saeid" sort="Ghavami, Saeid" uniqKey="Ghavami S" first="Saeid" last="Ghavami">Saeid Ghavami</name><affiliation wicri:level="4"><nlm:affiliation>Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada; Research Institute in Oncology and Hematology, CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada; Faculty of Medicine, Katowice School of Technology, Katowice, Poland. Electronic address: saeid.ghavami@umanitoba.ca.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada; Research Institute in Oncology and Hematology, CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada; Faculty of Medicine, Katowice School of Technology, Katowice</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32561291</idno><idno type="pmid">32561291</idno><idno type="doi">10.1016/j.ejphar.2020.173288</idno><idno type="pmc">PMC7297682</idno><idno type="wicri:Area/Main/Corpus">000C98</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000C98</idno><idno type="wicri:Area/Main/Curation">000C98</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000C98</idno><idno type="wicri:Area/Main/Exploration">000C98</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management?</title><author><name sortKey="Sureda, Antoni" sort="Sureda, Antoni" uniqKey="Sureda A" first="Antoni" last="Sureda">Antoni Sureda</name><affiliation wicri:level="1"><nlm:affiliation>Research Group in Community Nutrition and Oxidative Stress, University of Balearic Islands, Health Research Institute of Balearic Islands (IdISBa), and CIBEROBN (Physiopathology of Obesity and Nutrition), E-07122, Palma, Balearic Islands, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Research Group in Community Nutrition and Oxidative Stress, University of Balearic Islands, Health Research Institute of Balearic Islands (IdISBa), and CIBEROBN (Physiopathology of Obesity and Nutrition), E-07122, Palma, Balearic Islands</wicri:regionArea><wicri:noRegion>Balearic Islands</wicri:noRegion></affiliation></author><author><name sortKey="Alizadeh, Javad" sort="Alizadeh, Javad" uniqKey="Alizadeh J" first="Javad" last="Alizadeh">Javad Alizadeh</name><affiliation wicri:level="4"><nlm:affiliation>Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Nabavi, Seyed Fazel" sort="Nabavi, Seyed Fazel" uniqKey="Nabavi S" first="Seyed Fazel" last="Nabavi">Seyed Fazel Nabavi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Translational Medicine, Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Tehran, Iran; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Division of Translational Medicine, Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Tehran, Iran; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Berindan Neagoe, Ioana" sort="Berindan Neagoe, Ioana" uniqKey="Berindan Neagoe I" first="Ioana" last="Berindan-Neagoe">Ioana Berindan-Neagoe</name><affiliation wicri:level="1"><nlm:affiliation>Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; The Center for Advanced Medicine - Medfuture- "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; The Department for Functional Genomics and Experimental Pathology, The Oncology Institute, "Prof. Dr. Ion Chiricuta", Cluj-Napoca, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; The Center for Advanced Medicine - Medfuture- "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; The Department for Functional Genomics and Experimental Pathology, The Oncology Institute, "Prof. Dr. Ion Chiricuta", Cluj-Napoca</wicri:regionArea><wicri:noRegion>Cluj-Napoca</wicri:noRegion></affiliation></author><author><name sortKey="Cismaru, Cosmin Andrei" sort="Cismaru, Cosmin Andrei" uniqKey="Cismaru C" first="Cosmin Andrei" last="Cismaru">Cosmin Andrei Cismaru</name><affiliation wicri:level="1"><nlm:affiliation>Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Functional Sciences, Immunology and Allergology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Functional Sciences, Immunology and Allergology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca</wicri:regionArea><wicri:noRegion>Cluj-Napoca</wicri:noRegion></affiliation></author><author><name sortKey="Jeandet, Philippe" sort="Jeandet, Philippe" uniqKey="Jeandet P" first="Philippe" last="Jeandet">Philippe Jeandet</name><affiliation wicri:level="3"><nlm:affiliation>Research Unit, Induced Resistance and Plant Bioprotection, EA 4707, SFR Condorcet FR CNRS 3417, Faculty of Sciences, University of Reims Champagne-Ardenne, PO Box 1039, 51687, Reims Cedex 2, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Research Unit, Induced Resistance and Plant Bioprotection, EA 4707, SFR Condorcet FR CNRS 3417, Faculty of Sciences, University of Reims Champagne-Ardenne, PO Box 1039, 51687, Reims Cedex 2</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Los, Marek J" sort="Los, Marek J" uniqKey="Los M" first="Marek J" last="Łos">Marek J. Łos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Pomeranian Medical University, Szczecin, Poland. Electronic address: mjelos@gmail.com.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Clementi, Emilio" sort="Clementi, Emilio" uniqKey="Clementi E" first="Emilio" last="Clementi">Emilio Clementi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical and Clinical Sciences, "Luigi Sacco" (DIBIC), Università Degli Studi di Milano, 20157, Milano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedical and Clinical Sciences, "Luigi Sacco" (DIBIC), Università Degli Studi di Milano, 20157, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Nabavi, Seyed Mohammad" sort="Nabavi, Seyed Mohammad" uniqKey="Nabavi S" first="Seyed Mohammad" last="Nabavi">Seyed Mohammad Nabavi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Translational Medicine, Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Tehran, Iran; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: Nabavi208@gmail.com.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Division of Translational Medicine, Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Tehran, Iran; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Ghavami, Saeid" sort="Ghavami, Saeid" uniqKey="Ghavami S" first="Saeid" last="Ghavami">Saeid Ghavami</name><affiliation wicri:level="4"><nlm:affiliation>Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada; Research Institute in Oncology and Hematology, CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada; Faculty of Medicine, Katowice School of Technology, Katowice, Poland. Electronic address: saeid.ghavami@umanitoba.ca.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada; Research Institute in Oncology and Hematology, CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada; Faculty of Medicine, Katowice School of Technology, Katowice</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author></analytic><series><title level="j">European journal of pharmacology</title><idno type="eISSN">1879-0712</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alveolar Epithelial Cells (cytology)</term><term>Alveolar Epithelial Cells (drug effects)</term><term>Alveolar Epithelial Cells (metabolism)</term><term>Alveolar Epithelial Cells (virology)</term><term>Betacoronavirus (metabolism)</term><term>Clathrin-Coated Vesicles (drug effects)</term><term>Clathrin-Coated Vesicles (metabolism)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (virology)</term><term>Endocytosis (drug effects)</term><term>Endoplasmic Reticulum (drug effects)</term><term>Endoplasmic Reticulum (metabolism)</term><term>Endosomes (drug effects)</term><term>Endosomes (metabolism)</term><term>Humans (MeSH)</term><term>Ionophores (pharmacology)</term><term>Ionophores (therapeutic use)</term><term>Pandemics (MeSH)</term><term>Peptidyl-Dipeptidase A (metabolism)</term><term>Pneumonia, Viral (drug therapy)</term><term>Pneumonia, Viral (virology)</term><term>Unfolded Protein Response (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Betacoronavirus (métabolisme)</term><term>Endocytose (effets des médicaments et des substances chimiques)</term><term>Endosomes (effets des médicaments et des substances chimiques)</term><term>Endosomes (métabolisme)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (virologie)</term><term>Ionophores (pharmacologie)</term><term>Ionophores (usage thérapeutique)</term><term>Pandémies (MeSH)</term><term>Peptidyl-Dipeptidase A (métabolisme)</term><term>Pneumocytes (cytologie)</term><term>Pneumocytes (effets des médicaments et des substances chimiques)</term><term>Pneumocytes (métabolisme)</term><term>Pneumocytes (virologie)</term><term>Pneumopathie virale (traitement médicamenteux)</term><term>Pneumopathie virale (virologie)</term><term>Réponse aux protéines mal repliées (effets des médicaments et des substances chimiques)</term><term>Réticulum endoplasmique (effets des médicaments et des substances chimiques)</term><term>Réticulum endoplasmique (métabolisme)</term><term>Vésicules tapissées de clathrine (effets des médicaments et des substances chimiques)</term><term>Vésicules tapissées de clathrine (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Ionophores</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Pneumocytes</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Alveolar Epithelial Cells</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Alveolar Epithelial Cells</term><term>Clathrin-Coated Vesicles</term><term>Endocytosis</term><term>Endoplasmic Reticulum</term><term>Endosomes</term><term>Unfolded Protein Response</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Endocytose</term><term>Endosomes</term><term>Pneumocytes</term><term>Réponse aux protéines mal repliées</term><term>Réticulum endoplasmique</term><term>Vésicules tapissées de clathrine</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Alveolar Epithelial Cells</term><term>Betacoronavirus</term><term>Clathrin-Coated Vesicles</term><term>Endoplasmic Reticulum</term><term>Endosomes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Betacoronavirus</term><term>Endosomes</term><term>Peptidyl-Dipeptidase A</term><term>Pneumocytes</term><term>Réticulum endoplasmique</term><term>Vésicules tapissées de clathrine</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Ionophores</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Ionophores</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Ionophores</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumocytes</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Alveolar Epithelial Cells</term><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Pandemics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Pandémies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In December 2019, many pneumonia cases with unidentified sources appeared in Wuhan, Hubei, China, with clinical symptoms like viral pneumonia. Deep sequencing analysis of samples from lower respiratory tract revealed a novel coronavirus, called 2019 novel coronavirus (2019-nCoV). Currently there is a rapid global spread. World Health Organization declare the disease a pandemic condition. The pathologic source of this disease was a new RNA virus from Coronaviridae family, which was named COVID-19. SARS-CoV-2 entry starts with the binding of the spike glycoprotein expressed on the viral envelope to ACE2 on the alveolar surface followed by clathrin-dependent endocytosis of the SARS-CoV-2 and ACE2 complex. SARS-CoV-2 enters the cells through endocytosis process, which is possibly facilitated, via a pH dependent endosomal cysteine protease cathepsins. Once inside the cells, SARS-CoV-2 exploits the endogenous transcriptional machinery of alveolar cells to replicate and spread through the entire lung. Endosomal acidic pH for SARS-CoV-2 processing and internalization is critical. After entering the cells, it possibly activates or hijack many intracellular pathways in favor of its replication. In the current opinion article, we will explain the possible involvement of unfolded protein response as a cellular stress response to the SARS-CoV-2 infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32561291</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>07</Day></DateCompleted><DateRevised><Year>2020</Year><Month>08</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0712</ISSN><JournalIssue CitedMedium="Internet"><Volume>882</Volume><PubDate><Year>2020</Year><Month>Sep</Month><Day>05</Day></PubDate></JournalIssue><Title>European journal of pharmacology</Title><ISOAbbreviation>Eur. J. Pharmacol.</ISOAbbreviation></Journal><ArticleTitle>Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management?</ArticleTitle><Pagination><MedlinePgn>173288</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0014-2999(20)30380-0</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ejphar.2020.173288</ELocationID><Abstract><AbstractText>In December 2019, many pneumonia cases with unidentified sources appeared in Wuhan, Hubei, China, with clinical symptoms like viral pneumonia. Deep sequencing analysis of samples from lower respiratory tract revealed a novel coronavirus, called 2019 novel coronavirus (2019-nCoV). Currently there is a rapid global spread. World Health Organization declare the disease a pandemic condition. The pathologic source of this disease was a new RNA virus from Coronaviridae family, which was named COVID-19. SARS-CoV-2 entry starts with the binding of the spike glycoprotein expressed on the viral envelope to ACE2 on the alveolar surface followed by clathrin-dependent endocytosis of the SARS-CoV-2 and ACE2 complex. SARS-CoV-2 enters the cells through endocytosis process, which is possibly facilitated, via a pH dependent endosomal cysteine protease cathepsins. Once inside the cells, SARS-CoV-2 exploits the endogenous transcriptional machinery of alveolar cells to replicate and spread through the entire lung. Endosomal acidic pH for SARS-CoV-2 processing and internalization is critical. After entering the cells, it possibly activates or hijack many intracellular pathways in favor of its replication. In the current opinion article, we will explain the possible involvement of unfolded protein response as a cellular stress response to the SARS-CoV-2 infection.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sureda</LastName><ForeName>Antoni</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Research Group in Community Nutrition and Oxidative Stress, University of Balearic Islands, Health Research Institute of Balearic Islands (IdISBa), and CIBEROBN (Physiopathology of Obesity and Nutrition), E-07122, Palma, Balearic Islands, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alizadeh</LastName><ForeName>Javad</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nabavi</LastName><ForeName>Seyed Fazel</ForeName><Initials>SF</Initials><AffiliationInfo><Affiliation>Division of Translational Medicine, Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Tehran, Iran; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berindan-Neagoe</LastName><ForeName>Ioana</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; The Center for Advanced Medicine - Medfuture- "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; The Department for Functional Genomics and Experimental Pathology, The Oncology Institute, "Prof. Dr. Ion Chiricuta", Cluj-Napoca, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cismaru</LastName><ForeName>Cosmin Andrei</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Functional Sciences, Immunology and Allergology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeandet</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Research Unit, Induced Resistance and Plant Bioprotection, EA 4707, SFR Condorcet FR CNRS 3417, Faculty of Sciences, University of Reims Champagne-Ardenne, PO Box 1039, 51687, Reims Cedex 2, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Łos</LastName><ForeName>Marek J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Department of Pathology, Pomeranian Medical University, Szczecin, Poland. Electronic address: mjelos@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clementi</LastName><ForeName>Emilio</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Biomedical and Clinical Sciences, "Luigi Sacco" (DIBIC), Università Degli Studi di Milano, 20157, Milano, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nabavi</LastName><ForeName>Seyed Mohammad</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Division of Translational Medicine, Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Tehran, Iran; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: Nabavi208@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghavami</LastName><ForeName>Saeid</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada; Research Institute in Oncology and Hematology, CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada; Faculty of Medicine, Katowice School of Technology, Katowice, Poland. Electronic address: saeid.ghavami@umanitoba.ca.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Eur J Pharmacol</MedlineTA><NlmUniqueID>1254354</NlmUniqueID><ISSNLinking>0014-2999</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007476">Ionophores</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.15.1</RegistryNumber><NameOfSubstance UI="D007703">Peptidyl-Dipeptidase A</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.17.-</RegistryNumber><NameOfSubstance UI="C413524">angiotensin converting enzyme 2</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D056809" MajorTopicYN="N">Alveolar Epithelial Cells</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D022163" MajorTopicYN="N">Clathrin-Coated Vesicles</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004705" MajorTopicYN="N">Endocytosis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004721" MajorTopicYN="N">Endoplasmic Reticulum</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011992" MajorTopicYN="N">Endosomes</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007476" MajorTopicYN="N">Ionophores</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007703" MajorTopicYN="N">Peptidyl-Dipeptidase A</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056811" MajorTopicYN="N">Unfolded Protein Response</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Endoplasmic reticulum</Keyword><Keyword MajorTopicYN="N">IRE1</Keyword><Keyword MajorTopicYN="N">PERK</Keyword><Keyword MajorTopicYN="N">Spliced XBP1</Keyword><Keyword MajorTopicYN="N">Unfolded protein response</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>04</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>06</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>6</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>6</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32561291</ArticleId><ArticleId IdType="pii">S0014-2999(20)30380-0</ArticleId><ArticleId IdType="doi">10.1016/j.ejphar.2020.173288</ArticleId><ArticleId IdType="pmc">PMC7297682</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li><li>Espagne</li><li>France</li><li>Iran</li><li>Italie</li><li>Pologne</li><li>Roumanie</li></country><region><li>Champagne-Ardenne</li><li>Grand Est</li><li>Manitoba</li></region><settlement><li>Reims</li><li>Winnipeg</li></settlement><orgName><li>Université du Manitoba</li></orgName></list><tree><country name="Espagne"><noRegion><name sortKey="Sureda, Antoni" sort="Sureda, Antoni" uniqKey="Sureda A" first="Antoni" last="Sureda">Antoni Sureda</name></noRegion></country><country name="Canada"><region name="Manitoba"><name sortKey="Alizadeh, Javad" sort="Alizadeh, Javad" uniqKey="Alizadeh J" first="Javad" last="Alizadeh">Javad Alizadeh</name></region></country><country name="Iran"><noRegion><name sortKey="Nabavi, Seyed Fazel" sort="Nabavi, Seyed Fazel" uniqKey="Nabavi S" first="Seyed Fazel" last="Nabavi">Seyed Fazel Nabavi</name></noRegion><name sortKey="Nabavi, Seyed Mohammad" sort="Nabavi, Seyed Mohammad" uniqKey="Nabavi S" first="Seyed Mohammad" last="Nabavi">Seyed Mohammad Nabavi</name></country><country name="Roumanie"><noRegion><name sortKey="Berindan Neagoe, Ioana" sort="Berindan Neagoe, Ioana" uniqKey="Berindan Neagoe I" first="Ioana" last="Berindan-Neagoe">Ioana Berindan-Neagoe</name></noRegion><name sortKey="Cismaru, Cosmin Andrei" sort="Cismaru, Cosmin Andrei" uniqKey="Cismaru C" first="Cosmin Andrei" last="Cismaru">Cosmin Andrei Cismaru</name></country><country name="France"><region name="Grand Est"><name sortKey="Jeandet, Philippe" sort="Jeandet, Philippe" uniqKey="Jeandet P" first="Philippe" last="Jeandet">Philippe Jeandet</name></region></country><country name="Pologne"><noRegion><name sortKey="Los, Marek J" sort="Los, Marek J" uniqKey="Los M" first="Marek J" last="Łos">Marek J. Łos</name></noRegion><name sortKey="Ghavami, Saeid" sort="Ghavami, Saeid" uniqKey="Ghavami S" first="Saeid" last="Ghavami">Saeid Ghavami</name></country><country name="Italie"><noRegion><name sortKey="Clementi, Emilio" sort="Clementi, Emilio" uniqKey="Clementi E" first="Emilio" last="Clementi">Emilio Clementi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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